New research examines the brain mechanisms behind rumination, focusing mainly on the subgenual prefrontal cortex (sgPFC) in the brain and another area in the brain, the default mode network (DMN), which is typically associated with reflection. The researchers explored how the relationships between these brain regions were tied to depressive ruminations.
They reviewed existing studies, and found that these depressive ruminations were more likely to appear in depressed patients when the sgPFC’s activation was closely coordinated with that of the DMN. This connectivity is what increases ruminating thoughts, the authors concluded. Medical Daily
Hamilton J, Farmer M, Fogelman P, Gotlib I. Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience Biological Psychiatry, 2015