CBT and antidepressants equally effective

Second generation antidepressants and CBT have evidence bases of benefits and harms in major depressive disorder. This meta-analysis concluded available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences.

HR Amick et al (2015) Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis BMJ 2015;351:h6019