CBT and antidepressants equally effective

Second generation antidepressants and CBT have evidence bases of benefits and harms in major depressive disorder. This meta-analysis concluded available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences.

HR Amick et al (2015) Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis BMJ 2015;351:h6019

 

Antidepressant use during pregnancy and the risk of autism spectrum disorder in children

The association between the use of antidepressants during gestation and the risk of autism spectrum disorder (ASD) in children is still controversial. The aetiology of ASD remains unclear, although studies have implicated genetic predispositions, environmental risk factors, and maternal depression.

This study found the use of antidepressants, specifically selective serotonin reuptake inhibitors, during the second and/or third trimester increases the risk of ASD in children, even after considering maternal depression.

T Bouhkris et al (2015) Antidepressant use during pregnancy and the risk of autism spectrum disorder in children JAMA